and, optionally, - heteroaryl, Retinoic acid receptor beta (RAR beta) (e.g., RAR beta 2) agonists. The present invention also relates to pharmaceutical compositions comprising such compounds and to methods for inducing or promoting neurite outgrowth, neurite outgrowth, and / or neurite outgrowth, for selectively activating RARbeta (e.g., RARbeta2) And in diseases and conditions such as neurological injuries such as those which are ameliorated by activation of RARbeta (e.g., RARbeta2) mediated by RARbeta (e.g., RARbeta2) To the use of such compounds and compositions both in vivo and in vitro ."/>
RAR -- BICYCLOHETEROARYL-HETEROARYL-BENZOIC ACID COMPOUNDS AS RETINOIC ACID RECEPTOR BETA RAR AGONISTS
The invention treatment compound field, and more specifically to certain bicyclo heteroaryl group of the formula - among (referred to for convenience, the present application as "BHBA compound" collectively) benzoic acid compound, and, optionally, - heteroaryl, Retinoic acid receptor beta (RAR beta) (e.g., RAR beta 2) agonists. The present invention also relates to pharmaceutical compositions comprising such compounds and to methods for inducing or promoting neurite outgrowth, neurite outgrowth, and / or neurite outgrowth, for selectively activating RARbeta (e.g., RARbeta2) And in diseases and conditions such as neurological injuries such as those which are ameliorated by activation of RARbeta (e.g., RARbeta2) mediated by RARbeta (e.g., RARbeta2) To the use of such compounds and compositions both in vivo and in vitro .
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