MKP-1 inhibits high NaCI-induced activation of p38 but does not inhibit the activation of TonEBP/OREBP: Opposite roles of p38α and p38δ

摘要

High NaCI rapidly activates p38 MAPK by phosphorylating it, the phosphorylation presumably being regulated by a balance of kinases and phosphatases. Kinases are known, but the phospha-tases are uncertain. Our initial purpose was to identify the phosphatas