Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli

摘要

The outer membrane (OM) of most Gram-negative bacteria contains lipopolysaccharide (LPS) in the outer leaflet. LPS, or endo-toxin, is a molecule of important biological activities. In the host, LPS elicits a potent immune response, while in the bacterium,