HDAC inhibitor reduces cytokine storm and facilitates induction of chimerism that reverses lupus in anti-CD3 conditioning regimen

Nainong Li; Dongchang Zhao; Mark Kirschbaum; Chunyan Zhang; Chia-Lei Lin; Ivan Todorov; Fouad Kandeel; Stephen Forman; Defu Zeng

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HDAC inhibitor reduces cytokine storm and facilitates induction of chimerism that reverses lupus in anti-CD3 conditioning regimen

机译：HDAC抑制剂可减少细胞因子风暴并促进诱导嵌合体，从而在抗CD3调节方案中逆转狼疮

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In allogeneic hematopoietic cell transplantation (HCT), donor T cell-mediated graft versus host leukemia (GVL) and graft versus autoimmune (GVA) activity play critical roles in treatment of hematological malignancies and refractory autoimmune diseases. Ho

机译：在同种异体造血细胞移植（HCT）中，供体T细胞介导的移植物抗宿主白血病（GVL）和移植物抗自身免疫（GVA）活性在血液系统恶性肿瘤和难治性自身免疫疾病的治疗中起着关键作用。何

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《Proceedings of the National Academy of Sciences of the United States of America》 |2008年第12期|4796-4801|共6页
作者
Nainong Li; Dongchang Zhao; Mark Kirschbaum; Chunyan Zhang; Chia-Lei Lin; Ivan Todorov; Fouad Kandeel; Stephen Forman; Defu Zeng;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类
关键词
anti-CD3 mAb; graft versus host disease; hematopoietic cell transplantation; systemic lupus erythematosus; suberoylanilide hydroxamic acid;

机译：抗CD3单克隆抗体;移植物抗宿主病;造血细胞移植;系统性红斑狼疮;辛二酰苯胺异羟肟酸;

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专利

1. Antithymocyte globulin affects the occurrence of acute and chronic graft-versus-host disease after a reduced-intensity conditioning regimen by modulating mixed chimerism induction and immune reconstitution. [J] . Nakai K, Mineishi S, Kami M, Transplantation: Official Journal of the Transplantation Society . 2003,第12期

机译：在降低强度的调节方案后，抗胸腺细胞球蛋白通过调节混合嵌合体诱导和免疫重建影响急性和慢性移植物抗宿主病的发生。
2. THE REVERSED PARADIGM OF CHIMERISM INDUCTION: DONOR CONDITIONING WITH RECIPIENT-DERIVED BONE MARROW CELLS AS A NOVEL APPROACH FOR TOLERANCE INDUCTION IN VASCULARIZED COMPOSITE ALLOTRANSPLANTATION [J] . Siemionow Maria, Rampazzo Antonio, Gharb Bahar Bassiri, Microsurgery. . 2016,第8期

机译：嵌合体诱导的逆向范式：接受者衍生的骨髓细胞的供体条件处理是血管复合复合异体移植耐受性诱导的新方法
3. THE REVERSED PARADIGM OF CHIMERISM INDUCTION: DONOR CONDITIONING WITH RECIPIENT-DERIVED BONE MARROW CELLS AS A NOVEL APPROACH FOR TOLERANCE INDUCTION IN VASCULARIZED COMPOSITE ALLOTRANSPLANTATION [J] . Siemionow Maria, Rampazzo Antonio, Gharb Bahar Bassiri, Microsurgery. . 2016,第8期

机译：逆向范例的嵌合诱导：带有受体源骨髓细胞的供体调理作为血管化复合分征性分析中耐受性诱导的新方法
4. Fludarabine Phosphete and Melphalan - An Immunosuppressive Reduced Intensity Conditioning (RIC) Regimen for AUogeneic Stem Cell Transplantation in Patients with a Range of Hematological Malignancies [C] . G. Jackson, C. Richardson, G. Morgan, European Haematology Association . 2002

机译：Fludarabine phospete和Melphalan - 一种免疫抑制性降低的强度调理（RIC）治疗患者血液学恶性肿瘤患者的促孕酮干细胞移植方案
5. Conjugated linoleic acid (CLA) prolongs the survival and reduces cachexia of the autoimmune NZB/W F1 mouse: Role of cytokine regulation by CLA in body weight wasting and murine systemic lupus erythematosus. [D] . Yang, Ming-Der. 2002

机译：共轭亚油酸（CLA）延长了自身免疫性NZB / W F1小鼠的存活率并降低了恶病质：CLA调节细胞因子在体重减轻和小鼠系统性红斑狼疮中的作用。
6. HDAC inhibitor reduces cytokine storm and facilitates induction of chimerism that reverses lupus in anti-CD3 conditioning regimen [O] . Nainong Li, Dongchang Zhao, Mark Kirschbaum, 2008

机译：HDAC抑制剂可减少细胞因子风暴并促进诱导嵌合体从而在抗CD3调节方案中逆转狼疮
7. HDAC inhibitor reduces cytokine storm and facilitates induction of chimerism that reverses lupus in anti-CD3 conditioning regimen [O] . Li, Nainong, Zhao, Dongchang, Kirschbaum, Mark, 2008

机译：HDAC抑制剂可减少细胞因子风暴并促进诱导嵌合体，从而在抗CD3调节方案中逆转狼疮

HDAC inhibitor reduces cytokine storm and facilitates induction of chimerism that reverses lupus in anti-CD3 conditioning regimen

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