Differential curvature sensing and generating activities of dynamin isoforms provide opportunities for tissue-specific regulation

摘要

The plasma membrane, the envelope that surrounds all living cells, serves as both a physical barrier and a platform for communication between cells and their environment. Thus, the transport of molecules in vesicles from the plasma membrane into the cell is highly orches- trated. The major process by which cell surface proteins such as signaling receptors and transporters are internalized is dubbed clathrin-mediated en-docytosis, named after the protein clathrin, which decorates the vesicles that ferry molecules into the cell. Clathrin-mediated endocytosis is also involved in the uptake of nutrients and other macromolecular cargo, and it is made possible by the assembly of the clathrin coat and other curvature-generating proteins that deform the underlying plasma membrane into clathrin-coated pits, which concentrate cargo, invaginate, and pinch off to form clathrin-coated endocytic vesicles.