Increasing evidence supports the notion that an aberrant microenviron-ment facilitates cancer development. The mechanisms underlying the phenotypic changes and the tumor-promoting function of cancer-associated stroma remain largely unknown. Overexpression of the chromatin remodeling protein Hmga2 in the stroma leads to the formation of multifocal prostatic precancerous lesions in the neighboring naive epithelium in a paracrine Wnt-dependent manner.
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