Shared signaling pathways among gasotransmitters

摘要

Gasotransmitters, including NO, CO, and H_2S, are a group of endogenously produced gas molecules that are membrane-permeable and share similar molecular targets (1). Gasotransmitters may antagonize or potentiate each other's cellular effects at three levels: their production, their downstream molecular targets, and the direct chemical interaction among themselves. The study published in PNAS by Coletta et al. (2) presents an interesting example of how the interaction of gasotransmitters converges at the same downstream molecular target. Coletta