Role of the translationally controlled tumor protein in DNA damage sensing and repair

摘要

In humans, DNA can be damaged by various endogenous and environmental agents, leading to various disorders. Therefore mechanisms must exist to protect or repair DNA. At high doses, ionizing radiation is known to cause excessive DNA damage, often followed by cancer or degenerative diseases. Here, we studied cellular responses to low doses of ionizing radiation that are typical of certain occupational activities or diagnostic radiography. Surprisingly, we observed significant adaptive responses when normal human cells were exposed to low doses of cesium-137 y rays. We also identified and characterized the specific protein involved in this response.