Cell cycle-regulated binding of nuclear proteins to elements within a mouse H3.2 histone gene

摘要

The histone gene family in mammals consists of 15-20 genes for each class of nucleosomal histone protein. These genes are classified as either replication-dependent or - independent in regard to their expression in the cell cycle. The expression of the replication-dependent histone genes in- creases dramatically as the cell prepares to enter S phase. Using mouse histone genes, we previously identified a coding region activating sequence (CRAS) involved in the up- regulation of at least two (H2a and H3) and possibly all nucleosomal replication-dependent histone genes.