Macrophage inflammatory protein-2: Chromosomal regulation in rat small intestinal epithelial cells

摘要

Nonpathogenic, resident bacteria participate in the pathogenesis of inflammation in the small intestine, but the molecular messages produced by such bacteria are un- known. Inflammatory responses involve the recruitment of specific leukocyte subsets. We, therefore, hypothesized that butyrate, a normal bacterial metabolite, may modulate che- mokine secretion by epithelial cells, by amplifying their re- sponse to proinflammatory signals. We studied the expression of the chemokine, macrophage inflammatory protein-2 (MIP-2) by the rat small intestinal epithelial cell line, IEC-6. Cells were stimulated with lipopolysaccharide or with inter- leukin 1β (IL-1β) and incubated with sodium butyrate.