ATP-Binding Cassette Transporter G2 Mediates the Efflux of Phototoxins on the Luminal Membrane of Retinal Capillary Endothelial Cells

Tomoko Asashima; Satoko Hori; Sumio Ohtsuki; Masanori Tachikawa; Masahiko Watanabe; Chisato Mukai; Shinji Kitagaki; Naoki Miyakoshi; Tetsuya Terasaki

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ATP-Binding Cassette Transporter G2 Mediates the Efflux of Phototoxins on the Luminal Membrane of Retinal Capillary Endothelial Cells

机译：ATP结合盒式转运蛋白G2介导视网膜上毛细血管内皮细胞的光膜上的光毒素流出。

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摘要

The purpose of this study was to clarify the localization and function of the ATP-binding cassette transporter G2 (ABCG2; BCRP/MXR/ABCP) in retinal capillary endothelial cells, which form the inner blood–retinal barrier, as an efflux transport system.

机译：本研究的目的是阐明ATP结合盒转运蛋白G2（ABCG2; BCRP / MXR / ABCP）在视网膜毛细血管内皮细胞中的定位和功能，该毛细血管内皮细胞形成了内血-视网膜屏障，作为外排转运系统。

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来源
《Pharmaceutical Research》 |2006年第6期|1235-1242|共8页
作者
Tomoko Asashima; Satoko Hori; Sumio Ohtsuki; Masanori Tachikawa; Masahiko Watanabe; Chisato Mukai; Shinji Kitagaki; Naoki Miyakoshi; Tetsuya Terasaki;
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作者单位

Department of Molecular Biopharmacy and Genetics Graduate School of Pharmaceutical Sciences Tohoku University Aoba Aramaki Aoba-ku Sendai 980-8578 Japan;

Department of Molecular Biopharmacy and Genetics Graduate School of Pharmaceutical Sciences Tohoku University Aoba Aramaki Aoba-ku Sendai 980-8578 Japan;

Department of Molecular Biopharmacy and Genetics Graduate School of Pharmaceutical Sciences Tohoku University Aoba Aramaki Aoba-ku Sendai 980-8578 Japan;

Department of Molecular Biopharmacy and Genetics Graduate School of Pharmaceutical Sciences Tohoku University Aoba Aramaki Aoba-ku Sendai 980-8578 Japan;

Department of Anatomy Hokkaido University School of Medicine Sapporo 060-8638 Japan;

Division of Pharmaceutical Sciences Graduate School of Natural Science and Technology Kanazawa University Kakuma-machi Kanazawa 920-1192 Japan;

Division of Pharmaceutical Sciences Graduate School of Natural Science and Technology Kanazawa University Kakuma-machi Kanazawa 920-1192 Japan;

Division of Pharmaceutical Sciences Graduate School of Natural Science and Technology Kanazawa University Kakuma-machi Kanazawa 920-1192 Japan;

Department of Molecular Biopharmacy and Genetics Graduate School of Pharmaceutical Sciences Tohoku University Aoba Aramaki Aoba-ku Sendai 980-8578 Japan;

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正文语种 eng
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关键词
ABC half-transporter; ABCG2/BCRP/MXR/ABCP; inner blood–retinal barrier; pheophorbide a; retinal capillary endothelial cell;

机译：ABC半转运蛋白;ABCG2 / BCRP / MXR / ABCP;内血-视网膜屏障;脱镁叶绿素a;视网膜毛细血管内皮细胞;

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专利

1. ATP-binding cassette transporter G2 mediates the efflux of phototoxins on the luminal membrane of retinal capillary endothelial cells. [J] . Asashima T, Hori S, Ohtsuki S, Pharmaceutical research . 2006,第6期

机译：ATP结合盒转运蛋白G2介导光毒素在视网膜毛细血管内皮细胞腔膜上的流出。
2. Expression of the ATP-binding Cassette Membrane Transporter, ABCG2, in Human and Rodent Brain Microvessel Endothelial and Glial Cell Culture Systems [J] . Gloria Lee, Karlo Babakhanian, Manisha Ramaswamy, Pharmaceutical Research . 2007,第7期

机译：ATP结合盒式膜转运蛋白ABCG2在人和啮齿动物脑微血管内皮细胞和神经胶质细胞培养系统中的表达
3. Expression of the ATP-binding cassette membrane transporter, ABCG2, in human and rodent brain microvessel endothelial and glial cell culture systems. [J] . Lee G, Babakhanian K, Ramaswamy M, Pharmaceutical research . 2007,第7期

机译：ATP结合盒式膜转运蛋白ABCG2在人和啮齿动物脑微血管内皮和神经胶质细胞培养系统中的表达。
4. ON-CHIP SINGLE VESICLE ANALYSES OF ATP-BINDING CASSETTE (ABC) TRANSPORTERS [C] . H. Sasaki, R. Kawano, T. Osaki, International Conference on Miniaturized Systems for Chemistry and Life Sciences . 2011

机译：ATP结合盒（ABC）转运蛋白的片上单囊泡分析
5. The Drosophila ATP-Binding Cassette transporter gene dMRP is related to the human Multidrug Resistance-associated Protein (MRP) family and functions as a xenobiotic transporter. [D] . Cogbill, Jolene Noelani Tarnay. 2008

机译：果蝇ATP结合盒式转运蛋白基因dMRP与人类多药耐药相关蛋白（MRP）家族有关，并作为外源生物转运蛋白。
6. Liver-X-receptor-mediated increase in ATP-binding cassette transporter A1 expression is attenuated by fatty acids in CaCo-2 cells: effect on cholesterol efflux to high-density lipoprotein. [O] . Shubha Murthy, Ella Born, Satya N Mathur, 2004

机译：CaCo-2细胞中的脂肪酸减弱了肝脏X受体介导的ATP结合盒转运蛋白A1表达的增加：影响胆固醇向高密度脂蛋白的流出。
7. Modulation of transendothelial permeability and expression of ATP-binding cassette transporters in cultured brain capillary endothelial cells by astrocytic factors and cell-culture conditions [O] . Michael T�r�k, J�rg Huwyler, Heike Gutmann, 2003

机译：通过星形胶质细胞因子和细胞培养条件调节培养脑毛细管内皮细胞ATP结合盒式盒转运蛋白的表达及表达

ATP-Binding Cassette Transporter G2 Mediates the Efflux of Phototoxins on the Luminal Membrane of Retinal Capillary Endothelial Cells

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