Chiral Bronsted acid catalyzed enantioselective hydrophosphonylation of imines: Asymmetric synthesis of alpha-amino phosphonates

摘要

A cyclic phosphoric acid derivative, derived from (R)-BINOL, was used as a chiral Bronsted acid (10 mol %) in hydrophosphonylation of aldimines with diisopropyl phosphite at room temperature. alpha-Amino phosphonates were obtained with good to high enantioselectivities.