Chiral Bronsted Acid-Catalyzed Formal α-Vinylation of Ketones for the Enantioselective Construction of Quaternary Carbon Centre

摘要

α-Vinyl ketones having an all carbon quaternary stereogenic centre at the α-position are important structural motif due to its prevalence in natural products and bioactive compounds. Therefore, the development of efficient methods for the construction of them is one of the important subjects in organic synthesis. Whereas the direct coupling of an enolate nucleophile with a vinyl electrophile by transition metal catalysis has particularly emerged as a potent strategy for the enantioselective construction of the α-vinyl ketones having all carbon quaternary stereogenic centre, the organocatalytic method has not been established.