Transition metal-free functionalized hydration of alkynes: one-pot synthesis of fluorinated β-keto-imidates using Selectfluor

摘要

A transition metal-free, four-component one-pot synthesis of polyfunctionalized fluorinated beta-keto-imidates via the functionalized hydration of alkynes has been described. The intermediate 1,3-ketoamino moiety was obtained from easily accessible arylpropioladehyde and arlyhydroxylamine and was treated with Selectfluor delivering fluorinated beta-keto-imidates. A wide variety of functional groups are tolerated under mild reaction conditions and the product applicability is highlighted.