In Vitro Radionuclide Therapy and In Vivo Scintigraphic Imaging of Alpha-Fetoprotein-Producing Hepatocellular Carcinoma by Targeted Sodium Iodide Symporter Gene Expression

Kwang Il Kim; Yong Jin Lee; Tae Sup Lee; Inho Song; Gi Jeong Cheon; Sang Moo Lim; June-Key Chung; Joo Hyun Kang

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In Vitro Radionuclide Therapy and In Vivo Scintigraphic Imaging of Alpha-Fetoprotein-Producing Hepatocellular Carcinoma by Targeted Sodium Iodide Symporter Gene Expression

机译：有针对性的碘化钠转运体基因表达的体外放射性核素治疗和生产α-甲胎蛋白的肝细胞癌的体内闪烁成像。

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Purpose This study aimed to develop a gene expression targeting method for specific imaging and therapy of alpha-fetoprotein (AFP)-producing hepatocellular carcinoma (HCC) cells, using an adenovirus vector containing the human sodium/iodide symporter (hNIS) gene driven by an AFP enhancer/promoter.

机译：目的本研究旨在开发一种基因表达靶向方法，用于使用α-胎蛋白（AFP）产生的肝细胞癌（HCC）细胞的特异性成像和治疗，该方法使用的是一种腺病毒载体，该载体包含由人驱动的人钠/碘转运体（hNIS）基因。 AFP增强剂/促进剂。

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来源
《Nuclear Medicine and Molecular Imaging》 |2013年第1期|1-8|共8页
作者
Kwang Il Kim; Yong Jin Lee; Tae Sup Lee; Inho Song; Gi Jeong Cheon; Sang Moo Lim; June-Key Chung; Joo Hyun Kang;
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作者单位

Molecular Imaging Research Center Korea Institute of Radiological and Medical Sciences">(1);

Molecular Imaging Research Center Korea Institute of Radiological and Medical Sciences">(1);

Molecular Imaging Research Center Korea Institute of Radiological and Medical Sciences">(1);

Molecular Imaging Research Center Korea Institute of Radiological and Medical Sciences">(1);

Molecular Imaging Research Center Korea Institute of Radiological and Medical Sciences">(1);

Department of Nuclear Medicine Korea Institute of Radiological and Medical Sciences">(2);

Department of Nuclear Medicine Korea Institute of Radiological and Medical Sciences">(2);

Department of Nuclear Medicine Seoul National University College of Medicine">(3);

Molecular Imaging Research Center Korea Institute of Radiological and Medical Sciences">(1);

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原文格式 PDF
正文语种 eng
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关键词
Hepatocellular carcinoma (HCC); Alpha-fetoprotein (AFP) promoter; Adenovirus; Tumor-targeted gene expression; Systemic delivery; Radioiodide therapy;

机译：肝细胞癌（HCC）;甲胎蛋白（AFP）启动子;腺病毒;肿瘤靶向基因表达;系统递送;放射性碘疗法;

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专利

1. In Vivo Scintigraphic Imaging of Antitumor Effects by Combined Radioiodine Therapy and Human Sodium Iodide Symporter Gene Immunotherapy [J] . Yun Choi, Yong Hyun Jeon, Jin Ho Paik, Molecular imaging . 2010,第3期

机译：放射碘疗法和人类碘化钠转运蛋白基因免疫疗法联合应用对体内抗肿瘤作用的闪烁闪烁成像
2. Establishment of a human hepatocellular carcinoma cell line highly expressing sodium iodide symporter for radionuclide gene therapy. [J] . Kang JH, Chung JK, Lee YJ, The Journal of Nuclear Medicine . 2004,第9期

机译：建立高表达放射性核素基因治疗的碘化钠转运蛋白的人肝癌细胞系。
3. Establishment of a Human Hepatocellular Carcinoma Cell Line Highly Expressing Sodium Iodide Symporter for Radionuclide Gene Therapy [J] . Dong Soo Lee, Jae Hoon Shin, Jae Min Jeong, The Journal of Nuclear Medicine . 2004,第9期

机译：放射性核素基因治疗高表达碘化钠转运体的人肝癌细胞系的建立
4. Imaging of adenovirus-mediated gene transfer of human sodium iodide symporter by Tc-99m pertechnetate scintigraphy in mice [C] . The First China-Japan-Korea conference of nuclear medicine . 2002

机译：Tc-99m高tech酸盐闪烁体显像技术在腺病毒介导的人碘化钠同向素基因转移中的成像
5. Regulation of sodium iodide symporter expression/function and tissue-targeted gene transfer of sodium iodide symporter. [D] . Lin, Xiaoqin. 2003

机译：碘化钠同向转运蛋白的表达/功能和组织靶向基因转移的调节。
6. In Vitro Radionuclide Therapy and In Vivo Scintigraphic Imaging of Alpha-Fetoprotein-Producing Hepatocellular Carcinoma by Targeted Sodium Iodide Symporter Gene Expression [O] . Kwang Il Kim, Yong Jin Lee, Tae Sup Lee, 2013

机译：靶向性碘化钠转运蛋白基因表达的α-甲胎蛋白生产性肝细胞的体外放射性核素治疗和体内闪烁成像。
7. In Vitro Radionuclide Therapy and In Vivo Scintigraphic Imaging of Alpha-Fetoprotein-Producing Hepatocellular Carcinoma by Targeted Sodium Iodide Symporter Gene Expression [O] . Kwang Il Kim, Yong Jin Lee, Tae Sup Lee, 2012

机译：体外放射性核素治疗和靶向碘化钠交响者基因表达的α-胎蛋白产生肝细胞癌的体内闪烁成像
8. Genetically Targeted Radiotherapy Utilizing the Human Sodium Iodide Symporter in Human Breast Carcinoma Cells [R] . Krager, K. 2007

机译：在人乳腺癌细胞中利用人体钠碘化物转运的基因靶向放射治疗

In Vitro Radionuclide Therapy and In Vivo Scintigraphic Imaging of Alpha-Fetoprotein-Producing Hepatocellular Carcinoma by Targeted Sodium Iodide Symporter Gene Expression

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