The application of fast multiparametric protocol MRI-based thrombolysis with rt-PA hyperacute cerebral infarction

摘要

Objective: To investigate the value of fast multiparametric protocol magnetic resonance imagingn(MRI)-based thrombolysis in hyperacute cerebral infarction.nMethods: Seventy-seven patients with acute ischemic stroke were examined by multiparametricnprotocol MRI and among them, 12 patients with hyperacute cerebral infarction were treated bynrecombinant tissue plasminogen activator (rt-PA) and followed up periodically by MRI.nResults: The 12 patients selected by FMPMRI to receive thrombolysis demonstrated clinicalnimprovement, with 90 day modified Rankin scale scores (mRs)(2 and life quality Barthel indexn(BI) of 80–100. The only complication involved one patient (8.3%) who developed annasymptomatic intracranial hemorrhage 3 weeks after receiving thrombolytics.nConclusion: Multiparametric protocols have significant clinical potential for the treatment ofnhyperacute stroke patients who are candidates for receiving intravenous thrombolytic therapy.nOur data suggest that patients suffering from hyperacute ischemic cerebral infarction that arenstrong candidates for intravenous thrombolytic therapy can be identified by multiparametricnprotocol MRI, especially to those whose time windows were undefined or beyond 3 hours afternsymptom onset. [Neurol Res 2008; 30: 344–347]