Cerebellar glioblastomas: pathophysiology, clinical presentation and management

摘要

Glioblastoma multiforme usually affects the cerebral hemispheres with the peak age of onset in the sixth or seventh decade, while cerebellar glioblastoma multiforme is a rare tumour especially in younger patients. Most result from de-differentiation from low grade astrocytoma (secondary glioblastoma) or can develop de novo (primary glioblastoma). Primary glioblastomas develop in older patients while secondary glioblastomas develop in younger patients and contain TP53 mutations as the earliest detectable change. We report a 28 year old patient with primary multi-focal cerebellar glioblastoma multiforme and review the pathophisiology, clinical presentation, diagnosis and treatment of cerebellar glioblastomas. Keywords Glioblastoma multiforme - Cerebellum - Primary glioblastoma - p53 - p73 Authors’ contributions Study concept and design: Grahovac and Habek. Acquisition of data: Grahovac, Tomac, Lambasa and Zoric. Analysis and interpretation of data: Grahovac, Tomac, Lambasa and Zoric. Drafting of the manuscript: Grahovac and Habek. Critical revision of the manuscript for important intellectual content: Grahovac, Tomac, Lambasa, Zoric and Habek. Administrative, technical, and material support: Grahovac and Habek.