机译:PI3K / PTEN / Akt通路状态影响高级神经胶质瘤细胞培养物对胰岛素样生长因子-1受体抑制剂NVP-AEW541的敏感性
Department of Medical Oncology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 02115;
rnDepartment of Oncology-Pathology, Karolinska Institutet, Cancer Center Karolinska, Stockholm, Sweden;
rnDepartment of Oncology-Pathology, Karolinska Institutet, Cancer Center Karolinska, Stockholm, Sweden;
Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland;
rnDepartment of Oncology-Pathology, Karolinska Institutet, Cancer Center Karolinska, Stockholm, Sweden;
Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland;
rnDepartment of Oncology-Pathology, Karolinska Institutet, Cancer Center Karolinska, CCK, R8:03, Karolinska University Hospital, Stockholm, Stockholm SE-171 76, Sweden;
akt; glioblastoma multiforme; IGF-1 receptor; NVP-AEW541; PIK3CA; PTEN;
机译:七氟醚下调胰岛素样生长因子-1,以通过PI3K / AKT信号通路抑制细胞增殖,侵袭和触发胶质瘤的细胞凋亡
机译:乳腺癌细胞系对新型胰岛素样生长因子1受体(IGF-1R)抑制剂NVP-AEW541的敏感性取决于IRS-1表达的水平。
机译:用腺病毒介导的PTEN和PI3K抑制剂的组合治疗通过调节PI3K / AKT信号通路,体外和体内抑制恶性胶质瘤细胞生长
机译:噻唑烷-2,4-二酮类似物作为胰岛素样生长因子-1受体(IGF-1R)抑制剂的发现和SAR通过分层虚拟筛选
机译:多靶点受体酪氨酸激酶抑制剂利尼法尼(ABT-869)通过磷酸肌醇3激酶(PI3K)/ AKT依赖性信号传导途径诱导凋亡并抑制白血病细胞的增殖。
机译:PI3K / PTEN / Akt通路状态影响高级神经胶质瘤细胞培养物对胰岛素样生长因子-1受体抑制剂NVP-AEW541的敏感性
机译:PI3K / PTEN / Akt通路状态影响高级神经胶质瘤细胞培养物对胰岛素样生长因子-1受体抑制剂NVP-AEW541的敏感性