Recent advances in the ability to generate and solubilize ~(13)C hyper-polarized compounds followed by injection and analysis with ~(13)C MR spectroscopy have given investigators the ability to non-invasively follow the fate of specific metabolites in vivo. Hyperpo-larized probes can be used to monitor conversion of pyruvate to lactate, to measure pH, and to assess redox potential among other uses. 2-Hydroxyglutarate (2-HG) production is a target for anti-glioma therapy in tumors with mutant isocitrate dehydro-genase 1 (IDH1). Chaumeil and colleagues performed ~(13)C MR spectroscopy to follow the fate of hyperpolarized [1-~(13)C] alpha-ketoglutarate (α-KG) in mutant and wildtype IDH1 tumors.
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