Hominoid-specific enzyme GLUD2 and IDH-mutant glioma

摘要

Mutation of isocitrate dehydrogenase 1 (IDH1), or the homologous gene IDH2, is thought to be the initiating event for a majority of secondary glioblastoma (GBM) and lower-grade diffuse gliomas. The most common mutation in this gene is IDH1~(R132H), which alters the activity of this enzyme, redirecting metabolic flux to generate 2-hydroxyglutarate (2-HG) at the expense of α-ketoglutarate (α-KG). The mechanism by which this mutation contributes to tumor growth, however, is not well understood.