Outcome of patients with intracranial non-germinomatous germ cell tumors-lessons from the SIOP-CNS-GCT-96 trial

Calaminus Gabriele; Frappaz Didier; Kortmann Rolf Dieter; Krefeld Barbara; Saran Frank; Pietsch Torsten; Vasiljevic Alexandre; Garre Maria Luisa; Ricardi Umberto; Mann Jillian R.; Gobel Ulrich; Alapetite Claire; Murray Matthew J.; Nicholson James C.

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Outcome of patients with intracranial non-germinomatous germ cell tumors-lessons from the SIOP-CNS-GCT-96 trial

机译：SIOP-CNS-GCT-96试验得出的颅内非生殖细胞生殖细胞肿瘤患者的结果

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Background. Following promising results to increase survival and reduce treatment burden in intracranial non-germinomatous germ cell tumors (NGGCTs), we conducted a European study using dose-intense chemotherapy followed by risk-adapted radiotherapy.

机译：背景。在增加颅内非生殖器生殖细胞肿瘤（NGGCT）的生存率并减轻其治疗负担的令人鼓舞的结果之后，我们进行了一项欧洲研究，采用剂量密集型化学疗法，然后进行适应风险的放疗。

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来源
《Neuro-Oncology》 |2017年第12期|1661-1672|共12页
作者
Calaminus Gabriele; Frappaz Didier; Kortmann Rolf Dieter; Krefeld Barbara; Saran Frank; Pietsch Torsten; Vasiljevic Alexandre; Garre Maria Luisa; Ricardi Umberto; Mann Jillian R.; Gobel Ulrich; Alapetite Claire; Murray Matthew J.; Nicholson James C.;
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作者单位

Univ Childrens Hosp Bonn, Paediat Hematol Oncol, Bonn, Germany;

Ctr Leon Berard, Inst Hematooncol Pediat, Lyon, France;

Univ Leipzig, Radiat Therapy & Radiooncol, Leipzig, Germany;

Univ Childrens Hosp, Paediat Hematol Oncol, Munster, Germany;

Royal Marsden Hosp, Dept Radiotherapy, Sutton, Surrey, England;

Inst Neuropathol, Bonn, Germany;

Ctr Leon Berard, Dept Neuropathol, Lyon, France;

G Gaslini Childrens Hosp, Neurooncol, Genoa, Italy;

Univ Turin, Dept Oncol, Turin, Italy;

Birmingham Childrens Hosp, Paediat Oncol, Birmingham, W Midlands, England;

ESPED Univ Dusseldorf, Dusseldorf, Germany;

Inst Curie, Radiat Oncol, Paris, France;

Cambridge Univ Hosp, Paediat Oncol, Cambridge, England;

Cambridge Univ Hosp, Paediat Oncol, Cambridge, England;

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正文语种 eng
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关键词
chemotherapy; intracranial non-germinoma; radiotherapy; relapse; toxicity;

机译：化学疗法;颅内非生殖器瘤;放射疗法;复发;毒性;

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1. Management and Outcomes of Non-Irradiated Recurrences of Intracranial Non-Germinomatous Germ Cell Tumors [J] . Chan J., Imber B., Cheung C., Pediatric blood & cancer . 2018,第Suppla2期

机译：颅内非生殖细胞肿瘤非辐照复发的管理与结果
2. Management and Outcomes of Non-Irradiated Recurrences of Intracranial Non-Germinomatous Germ Cell Tumors [J] . Chan J., Imber B., Cheung C., Pediatric blood & cancer . 2018,第Suppla2期

机译：颅内非生殖细胞肿瘤非辐照复发的管理与结果
3. Proton Therapy for Intracranial Non-Germinomatous Germ Cell Tumors [J] . Sethi R., Yeap B. Y., Yock T. I., International Journal of Radiation Oncology, Biology, Physics . 2018,第3Suppla期

机译：颅内非生殖细胞肿瘤的质子疗法
4. Initial Salvage Therapy for Patients with Advanced Germ Cell Tumors: Do We Need a Randomized Trial? [C] . Darren R. Feldman Genitourinary Cancers Symposium . 2012

机译：初始救生患者患者治疗晚期胚芽细胞肿瘤：我们需要随机试验吗？
5. PRMT5 is an Essential Survival Factor for Ground State Pluripotency and Primordial Germ Cells: From Primordial Germ Cell Differentiation in vitro to Mammalian Germline in vivo [D] . Li, Ziwei 2014

机译：PRMT5是基态多能性和原始生殖细胞的必需生存因子：从体外原始生殖细胞分化到体内哺乳动物生殖细胞
6. Outcome of patients with intracranial non-germinomatous germ cell tumors—lessons from the SIOP-CNS-GCT-96 trial [O] . Gabriele Calaminus, Didier Frappaz, Rolf Dieter Kortmann, 2017

机译：颅内非生殖细胞生殖细胞肿瘤患者的治疗效果—来自SIOP-CNS-GCT-96试验的教训

Outcome of patients with intracranial non-germinomatous germ cell tumors-lessons from the SIOP-CNS-GCT-96 trial

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