Rapamycin has dual opposing effects on proteinuric experimental nephropathies: is it a matter of podocyte damage?

摘要

Background. In clinical renal transplantation, an increase in proteinuria after conversion from calcineurin inhibitors to rapamycin has been reported. In contrast, there are studies showing a nephro-protective effect of rapamycin in proteinuric diseases characterized by progressive interstitial inflammatory fibrosis.