Renoprotective effect of rosuvastatin in DOCA–salt hypertensive rats

摘要

Background. Pleiotropic effects of statins represent potential mechanisms for the treatment of end organ damage in hypertension. This study has investigated the effects of rosuvastatin (10 mg/kg/day) on renal function impairment, glomerulosclerosis and tubulointerstitial fibrosis in deoxycorticosterone acetate (DOCA)–salt hypertensive (DSH) rat.