Association of −27TC and its haplotype at the putative promoter for IgA-specific receptor gene with IgA nephropathy amongn the Chinese Han population

摘要

Background. One-third to half of IgA nephropathy (IgAN) patients have raised serum IgA levels. Decreased clearance of IgA/IgA complex has been observed in IgAN patients. FCAR codes for IgA-specific receptor and plays an important role in IgA metabolism. Previous small sample-sized studies reported controversial findings in its association with IgAN.