Bone and mineral diseases

摘要

Introduction and Aims: KAI-4169 is a novel peptide agonist of the calcium-sensing receptor (CaSR). Previous studies have demonstrated that KAI-4169 inhibits parathyroid hormone (PTH) secretion in normal animals and in models of chronic kidney disease. The present studies extend these observations by examining the efficacy of KAI-4169 over several weeks on plasma PTH, soft tissue calcification and expression of parathyroid gland vitamin D receptor (VDR) protein in 5/6 nephrectomized rats (5/6 Nx). A comparison between KAI-4169 and cinacalcet was also conducted.