Few can interlace their autobiography with the evolution of a scientific paradigm. Even fewer can weave such a story seamlessly. Eric Kandel is one of these. His career, from his training in Harry Grundfest's laboratory at Columbia University in New York more than fifty years ago to a remarkably productive present, also at Columbia, epitomizes his ardent reductionist approach to the neural sciences. Its formal pinnacle was the Nobel Prize in Physiology or Medicine, which Kandel shared in 2000 with Arvid Carlsson and Paul Greengard for their discoveries concerning signal transduction in the nervous system.
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