The destruction of proteins is as important as their synthesis for the maintenance of protein homeostasis in cells. In eukaryotes, the ubiquitin-proteasome system is responsible for most of this protein degradation: the small protein ubiquitin acts as a death warrant, tagging and targeting other proteins to the large proteolytic chamber of the proteasome.rnThe discovery in the 1970s that certain proteins are ubiquitylated before degradation was awarded the 2004 Nobel Prize in Chemistry. It is now known that ubiquitin-mediated destruction plays a crucial part in cell-cycle regulation, DNA repair, cell growth and immune function, as well as in hormone-mediated signalling in plants. More recently, ubiquitin has been shown to have numerous non-proteolytic functions, including involvement in vesicular trafficking pathways, regulation of histone modification and viral budding.
展开▼
