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摘要

It has been suggested that recent increases in the prevalence of autoinflammatory diseases may be due in part to dietary change, but the possible mechanisms involved remain poorly defined. This study shows that mice lacking the Pstpip2~(cmo) gene, a model for osteomyelitis, are fully protected against inflammatory bone disease and bone erosion when fed a diet that is rich in fat and cholesterol. Protection correlates with a shift in the intestinal microbiota, including marked reductions in Prevotella levels, and significantly reduced pro-interleukin-1 levels in circulating immune cells.