A CAD system design to diagnosize alzheimers disease from MRI brain images using optimal deep neural network

摘要

Memory related issues in brain are mainly caused by Alzheimer disease (AD) which is the most common form of dementia. This disease must be diagnosed in its prodromal stage known as Mild Cognitive Impairment (MCI) also it needs an accurate detection and classification technique. In this paper, a computer-aided diagnosis (CAD) system is implemented on Magnetic resonance imaging (MRI) data from ADNI database. This disease highly affects the Hippocampus and cerebrum regions which are normally found in the grey matter region of brain. At first, MNI/ICBM atlas space of every three dimensional MRI images are constructed using normalization procedure, then grey matter region of brain is extracted. Subsequently, feature extraction is done by two dimensional Gabor filter in three scales and eight orientations. Then, the proposed optimal Deep Neural Network (DNN) classifier is used to classify the images as Cognitive normal (CN), Alzheimer disease (AD), and Mild Cognitive Impairment (MCI). Here, DNN classifier is optimized by selecting optimal weight parameter using Enhanced Squirrel Search Algorithm. The experimental results prove an efficiency of the proposed method using MR images. The proposed algorithm beats existing techniques in terms of accuracy, sensitivity, and specificity.