MRI with Magnetic Nanoparticles Monitors Downstream Anti-Angiogenic Effects of mTOR Inhibition

Alexander R. Guimaraes; Robert Ross; Jose L. Figuereido; Peter Waterman; Ralph Weissleder

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MRI with Magnetic Nanoparticles Monitors Downstream Anti-Angiogenic Effects of mTOR Inhibition

机译：具有磁性纳米粒子的MRI监测mTOR抑制作用的下游抗血管生成作用

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To study the effect of mammalian target of rapamycin (mTOR) inhibition on angiogenesis with magnetic resonance imaging (MRI) using magnetic iron oxide nanoparticles (MNP).

机译：要研究哺乳动物雷帕霉素靶标（mTOR）抑制作用对使用磁性氧化铁纳米粒子（MNP）的磁共振成像（MRI）的血管生成的影响。

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来源
《Molecular Imaging and Biology》 |2011年第2期|p.314-320|共7页
作者
Alexander R. Guimaraes; Robert Ross; Jose L. Figuereido; Peter Waterman; Ralph Weissleder;
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作者单位

Center for Molecular Imaging Research, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA;

Lank Center for Genitourinary Oncology, Dana Farber Cancer Institute, Boston, MA, USA;

Center for Molecular Imaging Research, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA;

Center for Molecular Imaging Research, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA;

Center for Molecular Imaging Research, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA;

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正文语种 eng
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关键词
Magnetic resonance imaging; MRI; Magnetic nanoparticle imaging; Ultrasmall superparamagnetic iron oxide nanoparticle; Renal cell cancer; mTOR; Angiogenesis;

机译：磁共振成像;核磁共振成像;磁性纳米粒子成像;超小型超顺磁性氧化铁纳米粒子;肾细胞癌;mTOR;血管生成;

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专利

1. MRI with magnetic nanoparticles monitors downstream anti-angiogenic effects of mTOR inhibition. [J] . Guimaraes AR, Ross R, Figuereido JL, Molecular imaging and biology: MIB : the official publication of the Academy of Molecular Imaging . 2011,第2期

机译：带有磁性纳米粒子的MRI监测mTOR抑制的下游抗血管生成作用。
2. Potent and sustained inhibition of HIF-1alpha and downstream genes by a polyethyleneglycol-SN38 conjugate, EZN-2208, results in anti-angiogenic effects. [J] . Sapra P, Kraft P, Pastorino F, Angiogenesis . 2011,第3期

机译：聚乙二醇-SN38缀合物EZN-2208对HIF-1alpha和下游基因的强效和持续抑制作用可产生抗血管生成作用。
3. Potent and sustained inhibition of HIF-1α and downstream genes by a polyethyleneglycol-SN38 conjugate, EZN-2208, results in anti-angiogenic effects [J] . Puja Sapra, Patricia Kraft, Fabio Pastorino, Angiogenesis . 2011,第3期

机译：聚乙二醇-SN38缀合物EZN-2208对HIF-1α和下游基因的强效和持续抑制作用可产生抗血管生成作用
4. Identification of Downstream mTORC1/2 Activity Markers in Breast Cancer by Means of Label-free Phosphoproteomics [C] . Wilkes E., Cutillas P. R. American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2013

机译：通过无标记磷蛋白酶鉴定乳腺癌下游MTORC1 / 2活性标记的鉴定
5. Defining Anabolic Functions of ATF4 as a Downstream Effector of mTORC1 Signaling [D] . Torrence, Margaret Elizabeth. 2021

机译：定义ATF4的合成代谢功能作为MTORC1信令的下游执行器
6. 18F-labeled magnetic nanoparticles for monitoring anti-angiogenic therapeutic effects in breast cancer xenografts [O] . Yanshu Wang, Huanhuan Liu, Defan Yao, 2019

机译：18F标记的磁性纳米颗粒用于监测乳腺癌异种移植物中的抗血管生成治疗作用
7. 18F-labeled magnetic nanoparticles for monitoring anti-angiogenic therapeutic effects in breast cancer xenografts [O] . Yanshu Wang, Huanhuan Liu, Defan Yao, 2019

机译：18F标记的磁性纳米粒子，用于监测乳腺癌异种移植物中的抗血管生成治疗效果

MRI with Magnetic Nanoparticles Monitors Downstream Anti-Angiogenic Effects of mTOR Inhibition

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