A Comparative Study of the Glomerular Involvement in Two Different Strains of Mice Induced by Murine Graft-versus-Host Reaction

摘要

Graft-versus-Host reaction (GVHR) was induced in (BALB/c x A/J) F_1 (CAF_1) mice by the transfer of their parental (either BALB/c or A/J) spleen cells. As already reported, the transfer of BALB/c cells resulted in proteinuria and glomerulo-nephritis more frequently than that of A/J cells. Autoantibody production was more active after the transfer of BALB/c cells also. Morphological changes in the glomeruli were compared in this investigation. Ten weeks post transfer, major differences were observed in the mesangial areas and in capillary deposition. Subsequent crescent formations and hyalinosis were noticeable in the BALB/c → CAF_1 group. Increases in the number of deposits, proteinuria incidence and number of anti-DNA antibody producing cells were well-correlated. The most critical change seemed to be the degree of subepithelial electron dense deposition in the capillary walls. Thus, our investigation confirms the idea that auto-antibody derived immune complex results in glomerular deposition and proteinuria. This suggests that immune complex derived electron dense deposition seems to be correlated with the development of glomerular lesions in GVHR.