Involvement of apoptotic cell death in autoimmune diseases

摘要

A low rate of as well as a high rate of apoptotic cell death is involved in the development of various human autoimmune diseases. In rheumatoid arthritis(RA), im- paried apoptosis of rhemuatoid synovial cells appears to induce hyperplasia of the synovial tissues, whereas the ac- celeration of apoptotic cell death of osteoblasts may con- tribute to periarticular bone loss in patients with RA. Humoral factors including cytokines and growth factors Present in the rheumatoid synovial tissues modulate the Expression of apoptosis-related molecules in the cells, which Inhibits or stimulates the apoptotic process of synovial cells And osteoblasts.