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首页> 外文期刊>Materials science forum >Study on the Cytotoxicity In-vitro of Composite Materials Based on Poly(L-lactide-co-glycolide) and Bioactive Glass
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Study on the Cytotoxicity In-vitro of Composite Materials Based on Poly(L-lactide-co-glycolide) and Bioactive Glass

机译：聚（L-丙交酯-共-乙交酯）和生物活性玻璃复合材料的体外细胞毒性研究

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摘要

The effect of poly(L-lactide-co-glycolide)/bioactive glass (PLGA/BG) on cell attachment, proliferation and differentiation of L929 fibroblastic cells was investigated. The results of in-vitro cytotoxicity test indicated that the cells cultured in extract of PLGA/BG and on the surface of composite showed normal growth and proliferation. The cell proliferation and alkaline phosphatase (ALP) activity of fibroblast were significantly improved after 3 and 7 days of culture on PLGA/BG films in comparison with PLGA films. It can be concluded that the addition of bioactive glass into PLGA stimulates the proliferation and differentiation of fibroblastic cells. Therefore, PLGA/BG composites have a promising biological response as a potential biomaterial in medical field.
机译：研究了聚（L-丙交酯-乙交酯）/生物活性玻璃（PLGA / BG）对L929成纤维细胞细胞黏附，增殖和分化的影响。体外细胞毒性试验的结果表明，在PLGA / BG提取物中和复合物表面上培养的细胞显示出正常的生长和增殖。与PLGA膜相比，在PLGA / BG膜上培养3天和7天后，成纤维细胞的细胞增殖和碱性磷酸酶（ALP）活性显着提高。可以得出结论，在PLGA中添加生物活性玻璃可刺激成纤维细胞的增殖和分化。因此，PLGA / BG复合材料作为一种潜在的生物材料在医学领域具有广阔的发展前景。

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  • 来源
    《Materials science forum》 |2011年第2011期|p.384-389|共6页
  • 作者

    Zhihua Zhou; Yongyi Gao; Qingfeng Yi; Qingquan Liu; Lihua Liu;

  • 作者单位

    Key Laboratory of Theoretical Chemistry and Molecular Simulation of Ministry of Education,School of Chemistry and Chemical Engineering, Hunan University of Science and Technology,Xiangtan 411201, China;

    School of Physics, Hunan University of Science and Technology, Xiangtan 411201, China;

    Key Laboratory of Theoretical Chemistry and Molecular Simulation of Ministry of Education,School of Chemistry and Chemical Engineering, Hunan University of Science and Technology,Xiangtan 411201, China;

    Key Laboratory of Theoretical Chemistry and Molecular Simulation of Ministry of Education,School of Chemistry and Chemical Engineering, Hunan University of Science and Technology,Xiangtan 411201, China;

    Key Laboratory of Theoretical Chemistry and Molecular Simulation of Ministry of Education,School of Chemistry and Chemical Engineering, Hunan University of Science and Technology,Xiangtan 411201, China;

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    cytotoxicity; in-vitro; bioactive glass; poly (L-lactide-co-glycolide);

    机译：细胞毒性体外;生物活性玻璃聚（L-丙交酯-乙交酯）;

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