Room temperature preparation of fluorescent starch nanoparticles from starch-dopamine conjugates and their biological applications

摘要

AbstractFluorescent organic nanoparticles (FONs) have been regarded as the promising candidates for biomedical applications owing to their well adjustment of chemical structure and optical properties and good biological properties. However, the preparation of FONs from the natural derived polymers has been rarely reported thus far. In current work, we reported a novel strategy for preparation of FONs based on the self-polymerization of starch-dopamine conjugates and polyethyleneimine in rather mild experimental conditions, including air atmosphere, aqueous solution, absent catalysts and at room temperature. The morphology, chemical structure and optical properties of the resultant starch-based FONs were investigated by different characterization techniques. Biological evaluation results demonstrated that these starch-based FONs possess good biocompatibility and fluorescent imaging performance. More importantly, the novel strategy might also be extended for the preparation of many other carbohydrate polymers based FONs with different structure and functions. Therefore, this work opens a new avenue for the preparation and biomedical applications of luminescent carbohydrate polymers.Graphical abstractFluorescence organic nanoparticles with high fluorescent intensity, excellent water dispersibility and good biocompatibility were synthesized through the self-polymerization of starch-dopamine conjugates and polyethyleneimine.Display OmittedHighlights•Luminescent carbohydrate polymers from starch-dopamine conjugates•These FONs were fabricated by self-polymerization of dopamine and PEI.•These FONs showed excellent properties for biomedical applications.