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首页> 外文期刊>Materials Letters >Preparation of nanopartides embedded microcapsules (NEMs) and their application in drug release
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Preparation of nanopartides embedded microcapsules (NEMs) and their application in drug release

机译：纳米粒子包埋微胶囊的制备及其在药物释放中的应用

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摘要

The strategy to construct a novel drug delivery system of nanoparticle embedded microcapsules (NEMs) is reported in this work. The Chitosan/Alginate Nanoparticle Embedded Microcapsules (CS/Alg NEMs) have been successfully prepared by emulsion-gelation and high-voltage electrostatic droplet generator. The drug release behavior in vitro of the NEMs was studied, using Capecitabine (CAP) and 7-globulin as model drugs. The results demonstrated that the NEMs could control the drugs' release rate significantly, whether it is a small-molecular drug or peptide and protein. Also, the results indicated that the co-loading drugs exhibited an orderly release property. The NEMs exhibited a great potential for application in drug delivery for multi-functions and sustained release.
机译：在这项工作中报道了构建新型的纳米颗粒嵌入式微胶囊（NEMs）药物递送系统的策略。通过乳液凝胶化和高压静电液滴发生器已成功制备了壳聚糖/藻酸盐纳米颗粒嵌入式微囊（CS / Alg NEM）。使用卡培他滨（CAP）和7-球蛋白作为模型药物研究了NEM的体外药物释放行为。结果表明，无论是小分子药物还是肽和蛋白质，NEMs都能显着控制药物的释放速率。而且，结果表明，这些担载药物显示出有序的释放性能。 NEMs在多功能和持续释放的药物递送中显示出巨大的潜力。

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  • 来源
    《Materials Letters》 |2012年第2012期|p.48-50|共3页
  • 作者

    Yuangang Liu; Xuezhan Sun; Shibin Wang; Maobin Xie; Aizheng Chen; Ruimin Long;

  • 作者单位

    College of Chemical Engineering, Huaqiao University, Xiamen 361021, China ,Institute of Biomaterials and Tissue Engineering, Huaqiao University, Xiamen 361021, China;

    College of Chemical Engineering, Huaqiao University, Xiamen 361021, China ,Institute of Biomaterials and Tissue Engineering, Huaqiao University, Xiamen 361021, China;

    College of Chemical Engineering, Huaqiao University, Xiamen 361021, China ,Institute of Biomaterials and Tissue Engineering, Huaqiao University, Xiamen 361021, China;

    College of Chemical Engineering, Huaqiao University, Xiamen 361021, China ,Institute of Biomaterials and Tissue Engineering, Huaqiao University, Xiamen 361021, China;

    College of Chemical Engineering, Huaqiao University, Xiamen 361021, China ,Institute of Biomaterials and Tissue Engineering, Huaqiao University, Xiamen 361021, China;

    College of Chemical Engineering, Huaqiao University, Xiamen 361021, China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    composite materials; nanopartides; microcapsules; drug release;

    机译：复合材料;纳米粒子微胶囊;药物释放;

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