Synthesis and characterization of Mg, Zn and Sr-incorporated hydroxyapatite whiskers by hydrothermal method

摘要

The feasibility of incorporating high (M/M+Ca = 16 mol. %) and low (M/M+Ca = 4.76 mol. %) concentrations of Mg2+, Zn2+ and Sr2+, as divalent cations with interesting biological properties, into the structure of well-known bioceramic: hydroxyapatite (HA) was carefully assessed. An established hydrothermal synthesis method was employed for preparation of HA in whisker-like morphology. Consequently, the possibility of synthesizing HA whiskers (HAWs) with cationic substitutions and effects of the introduced ions on morphology, structure and composition of HA products were evaluated. Almost, all the cation-substituted preparations could maintain the apatite phase, while the decrease in crystallite size and crystallinity was obvious. Lattice parameters (a, c) of the hexagonal system of HA were also affected in accordance with the type and amount of substituting cation. Zn(2+ )and high amounts of Mg2+ dramatically inhibited formation of whisker-like apatite and promoted formation of a mixture of hexagonal prism-like and flaky bundles, or hexagonal and multifaceted morphologies, respectively. However, Sr2+ exhibited minimum inhibitory effect on HAWs formation. Therefore, Sr- and Mg-substituted (low concentration of Mg) HAWs could be prepared for their potential biomedical applications. (C) 2019 Elsevier B.V. All rights reserved.