Chitosan Functionalised Carbon-Nanotubes for Improved Drug Targeting to Cancer Cells and Tissues

摘要

Particles with high negative zeta potential had significantly diminished internalization in cells. The zeta potential of carbon-nanotubes is highly negative which repels the cells and tissues and have a negative effect from cell interaction point of view. An attempt has been made to derivatise CNT's using chitosan for increasing its bioadhesiveness and the zeta potential so that the efficiency of drug absorption by cancerous cells may be significantly increased. This is particularly helpful in targeting cancer cells because cancerous cells have more negative charge compared to normal cells. CMC-f-CNT's had a significantly high bioadhesion and low negative zeta potential. This would help in passive targeting and closer interaction of this nanomaterial with the cancer cells.