SKO1 deficiency extends chronological lifespan in Saccharomyces cerevisiae

摘要

Sko1 plays a key role in the control of gene expression by osmotic and oxidative stress in yeast We demonstrate that the decrease in chronological lifespan(CLS)of hog1Δcells was suppressed by SKO1 deletion,sko1Δsingle mutant cells were shown to have a longer CLS,thus implicating Sko1 in the regulation of their CLS.