Autosomal Dominant Polycystic Kidney Disease: Current and Emerging Treatments

摘要

Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common hereditary disorders. Over the last decade, knowledge of the pathology underlying this disease has increased rapidly. Attributing important roles to tubular cell ciliary functioning, cell proliferation and fluid secretion, subsequent alterations in levels of intracellular calcium, adenosine 3′,5′-cyclic monophosphate (cAMP) and activation of a variety of cellular kinases, including mammalian target of rapamycin (mTOR), has laid out the foundations for development of potentially effective treatments. This article we provide a review the specific treatment options in ADPKD.