Management and outcomes of cystic hygromas: experiencernof a tertiary center

摘要

Purpose Cystic hygroma (CH) is a fetal sonographicrnfinding with an incidence of 1%. Chromosomal abnormalitiesrnand structural malformations are commonly relatedrnwith CH. We aimed to describe our experience andrndetermine the association between diagnosis of CH andrnadverse pregnancy outcome.rnMethods We retrospectively reviewed data of prenatal CHrndiagnoses over a ten-year period. Cases were evaluated forrnmaternal age, gestational week at CH diagnosis, invasivernprocedure, karyotype result, associated abnormality andrnperinatal outcome. We categorized cases into two groups tornunderstand the impact of maternal age on perinatal outcomes,rnand the cut-off was 35 years old.rnResults Totally 28 individuals were enrolled in the study.rnThe median maternal age at birth was 27.5 years old, and 7rnpatients were over 35 years old. Karyotype results werernavailable for all individuals, and 15 had an abnormalrnchromosome (53.5%). Five fetuses had structural abnormalities,rnand they were all observed within patients underrn35 years old. Healthy fetuses (without any problem atrnantenatal screening and birth) were found to be only 14.3%rnin advanced maternal age (AMA) group and 33.3% inrnyoung mothers.rnConclusions Women with AMA and CH had a higher riskrnof having a baby with a chromosomal abnormality, asrncompared with younger women.