Age and CD4 count of vertically HIV-infected children at the time of diagnosis: what are independent predictors for beingn symptomatic and CD4 counts drop?

摘要

A review of the literature has revealed that data on HIV-infected clinical presentations, age at the time of diagnosis and level of immunosuppression in resource-poor settings are very limited. A multicenter retrospective and cross-sectional method was used to analyze 1163 children 5 years of age (mean ± SD age 4.9 ± 3.2). About 54% of children were symptomatic. Tuberculosis and chronic dermatologic disorders were the commonest co-infections. The severity of immunosuppression was highest in preschool children (46.6%) and early adolescents (41.3%). After adjustment for sex, age, pattern of feeding and hemoglobin level, multinomial logistic regression showed that CD4 count 200–499, 500–999 and Tigray ethnicity were independently associated with being symptomatic. More than one-third of the children were in a state of severe immunosuppression and more than half were immunologically eligible for antiretroviral treatment.