Calculated Globulin Adds Predictive Value to Hepatitis B Vaccine Response in HIV-infected Persons Independently of HIV Viral load and CD4 Cell Count

摘要

BackgroundResponse rates to hepatitis B (HBV) virus vaccine are low compared with the general population. Recent data suggest baseline total IgG levels add predictive value for vaccine failure. We retrospectively analyzed the relationship of calculated globulin (CG) levels with HBV vaccine response in participants in the U.S. Military HIV Natural History Study (NHS).