Group Ⅳ Metallocene-Mediated Synthesis of Fluoroaromatics via Selective Defluorination of Saturated Perfluorocarbons

摘要

Fluorocarbons are noted for their chemical inertness, which is a manifestation of the great strength of the C—F bond and the weak nature of metal fluorocarbon interactions. These same thermodynamic and kinetic considerations which tend to disfavor C—F activation have also been exploited in useful technological and medical applications of fluorocarbons. A recent example is the development of the "fluorous biphase system" by Horvath and Rabai at Exxon in which the low hydrocarbon solubility of catalysts decorated with perfluoroalkyl chains allows for facile separation of products from catalysts under homogeneous conditions.