Synthesis of Tethered Amine-Ru Complexes via Intramolecular Defluorination and Catalytic Application to Asymmetric Transfer Hydrogenation

摘要

Asymmetric transfer hydrogenation (ATH) of ketones is an efficient and practical synthetic method of chiral alcohols.1) Among bifunctional ATH catalysts, tethered Ru complexes containing a linkage between arene ligands and chiral diamine units have been developed as efficient and robust catalysts.2,3)