Identification by ~(15)N Refocused INADEQUATE MAS NMR of Intermolecular Hydrogen Bonding that Directs the Self-Assembly of Modified DNA Bases

摘要

Hydrogen bonding is a key interaction in determining the three-dimensional shape and hence the physiological function of bio-macromolecules.For example,hydrogen bonding between complementary CG and AT base pairs plays a central role in the structure of double-helical DNA.Considering the DNA bases,guanine is very versatile in terms of acting as both a hydrogen-bonding donor and acceptor.Indeed,guanine readily self-assembles in the presence of metal ions,such as Na~+,to form G-quartets (Figure la) that have been exploited by supramolecular chemistry,for example,in the construction of nanowires and biosensors.