Proximity-Induced Catalysis by the Protein Kinase ERK2

摘要

Protein phosphorylation regulates most aspects of life and is controlled by two families of enzymes:the protein kinases,which add phosphates to proteins,and the protein phosphatases,which remove them.In humans,approximately 500 protein kinases are responsible for the phosphorylation of some 10000 cellular proteins.Currently,it is not possible to predict with high accuracy which cellular protein will be a substrate for a particular protein kinase.The problem is complex because the structures of many of the kinases and substrates are unknown and often multiple sites in a protein are phosphorylated,frequently by more than one protein kinase.