Enantioselective Syn-Selective Scandium-Catalyzed Ene Reactions

摘要

The carbonyl-ene reaction continues to be a powerful C-C bond forming reaction.The first catalytic enantioselective variant using a chiral aluminum BINOL complex was reported by Yamamoto.Subsequently,Mikami and others have reported the use of titanium-based BINOL complexes as efficient catalysts for the carbonyl- ene reaction.Other metal cations that have also been used to effectively catalyze the asymmetric carbonyl-ene reaction include complexes derived from Co,Pd,Pt,Cr,Cu,and several lanmanides.