syn-Selective and Enantioselective Direct Cross-Aldol Reactions between Aldehydes Catalyzed by an Axially Chiral Amino Sulfonamide

摘要

The aldol reaction has long been recognized as one of the most fundamental tools for the construction of new carbon-carbon bonds.In this area,the cross-aldol reaction between two different aldehydes is known to be often problematic because of undesired side reactions,including dehydration of the product,self-aldol reaction,and multiple addition of the enolate to the aldol product.