Assembly and Charge Transfer in Hybrid TiO_2 Architectures Using Biotin-Avidin as a Connector

摘要

Coupling size-dependent optical and electrochemical properties of inorganic nanoparticles with the functionality of biomolecules enables site-selective chemistries that take advantage of integrated properties of hybrids.The functionalization of gold nanoparticles and quantum dots with biomolecules has enabled molecular recognition of oligonucleotides and optical communication between quantum dots and chemisorbed proteins.The wiring of redox enzymes with gold nanoparticles has facilitated electrical communication between the biocatalyst and electrode.We have recently developed hybrid nanocomposites which electronically link photoactive TiO_2 nanoparticles to DNA that can be used as a fingerprint of oligonucleotide hybridization.