PNA-DNA Duplexes,Triplexes,and Quadruplexes Are Stabilized with trans-Cyclopentane Units

摘要

Peptide nucleic acids (PNAs) derived from an aminoethyl glycine (aeg) backbone can bind to oligonucleotides to form duplexes,triplexes,and quadruplexes.While PNAs with the aeg backbone have been used in numerous applications,modified PNA derivatives that increase duplex stability have recently emerged.Our research has demonstrated that incorporation of (S,S-trans-cyclopentane (fcyp) units into the PNA backbone improves duplex stability and sequence specificity when binding DNA.